Goalkeeping vote of confidence?
Another big call is in goal.
Altay Bayindir retains his place despite his costly error in last week’s defeat to Arsenal, with Andre Onana staying on the bench.
A vote of confidence, or an early sign that Amorim prefers the Turkish international as his No 1?
Sesko continues to be eased in
Plenty of focus will be on Benjamin Sesko this afternoon — but United's £65m striker has to wait for his first start.
Ruben Amorim goes with Matheus Cunha through the middle, flanked by Mason Mount and Bryan Mbeumo.
It could be a statement of intent to ease Sesko in gradually — or a sign Amorim still isn't sure of his best XI.
Fulham team news: Muniz leads the line
Rodrigo Muniz is rewarded for his late equaliser at Brighton with a start up front this afternoon — meaning Raúl Jiménez drops to the bench.
Ryan Sessegnon is also handed a start as Marco Silva freshens up his side for the visit of United.
Fulham XI: Leno, Tete, Andersen, Bassey, Castagne; Berge, Lukic; Sessegnon, King, Iwobi; Muniz
Subs: Lecomte, Cuenca, Robinson, Reed, Cairney, Wilson, Adama, Smith Rowe, Jimenez
Man United team news: Sesko and Onana on the bench
Benjamin Sesko does not start. Not does goalkeeper Andre Onana. Both have to settle for a place among the substitutes as Altay Bayindir keeps his spot in goal, while Mason Mount supports Bryan Mbeumo and Matheus Cunha in attack.
United's only change from last weekend sees Diogo Dalot replaced by Amad Diallo.
Man United XI: Bayindir; Yoro, De Ligt, Shaw; Amad, Fernandes, Casemiro, Dorgu; Mbeumo, Mount, Cunha.
Subs: Onana, Dalot, Fredricson, Heaven, Maguire, Ugarte, Sesko, Zirkzee.
Sun shines on the Thames as Fulham eye home revival
For Fulham, the challenge is turning Craven Cottage back into a fortress. Marco Silva's side lost their final three home matches last season – a run the Portuguese has never endured before in his managerial career – and he will be desperate to stop the slide today.
The setting could hardly be better. The sun is out on the banks of the Thames, the Riverside Stand is already buzzing, and fans have been filing in early to take advantage of the £5 pint offer. With a sold-out crowd behind them, the Cottagers will hope to make this famous old ground an intimidating place once again.
All eyes on United's £198.5m attack
All eyes will be on United's £198.5m new-look frontline this afternoon. Ruben Amorim moved aggressively in the summer to bring in Benjamin Sesko (£65m), Matheus Cunha (£62.5m) and Bryan Mbeumo (£71m), hoping to finally fix a misfiring attack.
None of the trio managed to score on debut against Arsenal last weekend, but there were signs of promise. Cunha and Mbeumo both went close, only to be denied by David Raya, while Sesko came off the bench to make his first Premier League appearance since his record switch from RB Leipzig.
United fans will want to see one of them make the difference today.
Both teams chasing first win
It is matchweek in the Premier League and both sides are chasing their first win of the campaign.
Fulham left it late at Brighton last weekend, Rodrigo Muniz rescuing a point with a 97th-minute goal in a 1-1 draw at Brighton.
United, meanwhile, slipped to a narrow 1-0 defeat at home to Arsenal - but there was plenty of encouragement in Ruben Amorim's side's attacking display - as they registered 14 shots.